多物种蛋白转录后修饰位点PTMs的在线预测数据库

翻译后修饰（PTMs）是指一些蛋白质在生物合成后的氨基酸侧链修饰。有超过400种不同类型的PTMs影响着蛋白质功能的许多方面。这种修饰作为关键的分子调节机制发生，以调节各种细胞过程。这些过程对蛋白质的结构和功能有重大影响。PTMs的破坏会导致重要生物过程的功能障碍，从而导致各种疾病。发现PTMs的高通量实验方法是非常费力和耗时的。因此，迫切需要计算方法和强大的工具来预测PTMs。目前有大量的PTMs数据，这些数据可以通过许多在线数据库公开获取。

PTM示意性的流程图，显示了预测器如何为PTM预测工作。(A) 数据收集和数据集创建。(B) 特征选择。(C) 创建训练和测试模型。(D) 评价模型的性能。

		General statistics
	简称Acronym	覆盖的物种数量	PTM类型数量	Number of PTMs^a	^{数据和数据库的类型b}	URL网站
General database	dbPTM	More than 1000 organisms	130	S: ∼908 900 P: ∼557 700	Exp. and Pred. Secondary	http://dbptm.mbc.nctu.edu.tw
	BioGRID	71 organisms	6	S: ∼700 000 P: ∼419 400	Exp. Primary	https://orcs.thebiogrid.org
	Phosphosite Plus	26 organisms	7	S: ∼483 700 P: ∼20 200	Exp. Primary	https://www.phosphosite.org
	PTMCode v2	19 organisms	69	S: ∼316 500 P: ∼ 45 300	Exp. Secondary	http://ptmcode.embl.de
	qPTM	Human	10	S: ∼296 900 P: ∼19 600	Exp. Secondary	http://qptm.omicsbio.info/
	PLMD	176 organisms	20	S: ∼285 700 P: ∼53 500	Exp. Secondary	http://plmd.biocuckoo.org
	CPLM	122 organisms	12	S: ∼189 900 P: ∼45 700	Exp. Secondary	http://cplm.biocuckoo.org
	YAAM	Saccharomyces cerevisiae	19	S: ∼121 900 P: ∼680	Exp. Secondary	http://yaam.ifc.unam.mx
	HPRD	Human	9	S: ∼ 93 700 P: ∼30 000	Exp. Primary	http://www.hprd.org
	PHOSIDA	9 organisms	3	S: ∼80 000 P: ∼28 700	Exp. Secondary	http://www.phosida.com
	PTM-SD	7 model organisms	21	S: ∼10 600 P: ∼842	Exp. Secondary	http://www.dsimb.inserm.fr/dsimb_tools/PTM-SD
	WERAM	8 organisms	2	S: ∼ 900 P: ∼584	Exp. Secondary	http://weram.biocuckoo.org
Phosphorylation 磷酸化	EPSD	68 organisms	Phosphorylation	S: ∼1 616 800 P: ∼209 300	Exp. Secondary	http://epsd.biocuckoo.cn
	PhosphoNET	Human	Phosphorylation	S: ∼950 000 P: ∼20 000	Exp. and Pred. Secondary	http://www.phosphonet.ca
	RegPhos	Human, mouse and rat	Phosphorylation	S: ∼111 700 P: ∼ 18 700	Exp. and Pred. Secondary	http://140.138.144.141/∼RegPhos
	Phospho.ELM	Mainly model organisms	Phosphorylation	S: ∼42 900 P: ∼8600	Exp. Secondary	http://phospho.elm.eu.org
	Phospho3D	Mainly model organisms	Phosphorylation	S: ∼42 500 P: ∼8700	Exp. Secondary	http://www.phospho3d.org
	dbPSP	200 prokaryotic organisms	Phosphorylation	S: ∼19 300 P: ∼8600	Exp. Secondary	http://dbpsp.biocuckoo.cn/indExp.php
	pTestis	Mouse	Phosphorylation	S: ∼17 800 P: ∼3900	Exp. and Pred. Secondary	http://ptestis.biocuckoo.org
	LymPHOS	Human	Phosphorylation	S: ∼15 500 P: ∼4900	Exp. and Pred. Primary	https://www.lymphos.org
	P3DB	9 plant organisms	Phosphorylation	S: ∼14 600 P: ∼6400	Exp. and Pred.	http://www.p3db.org
Glycosylation 糖基化	UniPep	Human	N-glycosylation	S: ∼52 400 P: ∼40 100	Exp. and Pred.	http://www.unipep.org
	GlycoFly	Drosophila melanogaster	N-glycosylation	S: ∼740 P: ∼477	Exp. and Pred.	http://betenbaugh.jhu.edu/GlycoFly
	GlycoFish	Zebrafish	N-glycosylation	S: ∼269 P: ∼169	Exp. and Pred. Primary	http://betenbaugh.jhu.edu/GlycoFish
Ubiquitylation 泛素化	mUbiSiDa	7 model organisms	Ubiquitylation	S: ∼110 900 P: ∼ 35 400	Exp. Secondary	http://reprod.njmu.edu.cn/mUbiSiDa
S-palmitoylation 棕榈酰化	SwissPalm	17 organisms	S-palmitoylation	S: ∼1062 P: ∼664	Exp. and Pred. Secondary	https://swisspalm.org
S-nitrosylation 亚硝化作用	dbSNO	18 organisms	S-nitrosylation	S: ∼4200 P: ∼2200	Exp. Secondary	http://dbSNO.mbc.nctu.edu.tw