| 数据库名称 | 描述 | URL |
|---|---|---|
| dbSNP | SNPs for a wide range of organisms, including >150M human reference SNPs. | http://www.ncbi.nlm.nih.gov/snp |
| dbVar | Genomic structural variations (primarily CNVs) generated mostly by published studies of various organisms, including >2.1M human CNVs. | http://www.ncbi.nlm.nih.gov/dbvar |
| COSMIC | Primarily somatic mutations from expert curation and genome-wide screening, including >3.5M coding mutations. | http://cancer.sanger.ac.uk/cosmic |
| 1000 Genomes Project | Genomes of a large number of people to provide a comprehensive resource on human genetic variation, including >2.5K samples. | http://www.1000genomes.org |
| TCGA | Genomics and functional genomics data repository for >30 cancers across >10K samples. Primary data types include mutation, copy number, mRNA, and protein expression. | https://tcga-data.nci.nih.gov/tcga |
| GEO | Functional genomics data repository hosted by NCBI, including >1.6M samples. | http://www.ncbi.nlm.nih.gov/geo |
| ArrayExpress | Functional genomics data repository hosted by EBI, including >1.8M samples. | https://www.ebi.ac.uk/arrayexpress |
| GTEx | Transcriptomic profiles of normal tissues, including >7K samples across >45 tissue types. | http://www.gtexportal.org |
| CCLE | Genetic and pharmacologic characterization of >1,000 cancer cell lines. | http://www.broadinstitute.org/ccle |
| Human Protein Atlas | Expression of >17K unique proteins in cell lines, normal, and cancer tissues. | http://www.proteinatlas.org |
| Human Proteome Map | Expression of >30K proteins in normal tissues. | http://humanproteomemap.org |
| StringDB | Protein-protein interactions for >9M proteins from >2K organisms. | http://string-db.org |
| ENCODE | Protein-DNA interactions, including >1.4K ChIP-Seq experiments across ∼200 cell lines. | http://genome.ucsc.edu/ENCODE |
| Project Achilles | Genetic vulnerabilities across >100 genomically characterized cancer cell lines by genome-wide genetic perturbation reagents (shRNAs or Cas9/sgRNAs), including >11.2K genes. | http://www.broadinstitute.org/achilles |
| LINCS | Cellular responses upon the treatment of chemical/genetic perturbagen, including >1M gene expression profiles representing >5,000 compounds and >3,500 genes (shRNA and overexpression) in >15 cell lines. | http://lincscloud.org |
| Genomics of Drug Sensitivity in Cancer project | Drug sensitivity data of 140 drugs in >700 cancer cell lines. | http://www.cancerrxgene.org |
| ChEMBL | Bioactivities for drug-like small molecules, including >10K targets, >1.7M distinct compounds, and >13.5M activities. | https://www.ebi.ac.uk/chembl |
| PubChem | Chemical compounds and bioassay experiments, including >60M unique chemical compounds and >1.1M assays. | http://pubchem.ncbi.nlm.nih.gov |
| CMap | >6,000 drug gene expression profiles representing 1,309 compounds tested in 3 main cell lines. | http://www.broadinstitute.org/cmap |
| CTRP | Links genetic, lineage, and other cellular features of cancer cell lines to small-molecule sensitivity, including 860 cell lines and 461 compounds. | http://www.broadinstitute.org/ctrp.v2.2 |
| ImmPort | Clinical assessments in immunology along with molecular profiles, including 143 clinical studies/trials and 799 experiments on >22.4K subjects. | https://immport.niaid.nih.gov |
| ClinicalTrials.gov | Registry and results database of publicly and privately supported clinical studies, including >201.7K studies. | https://clinicaltrials.gov |
| PharmGKB | Genetic variations on drug response, including >3K diseases, >27K genes, and >3K drugs. | https://www.pharmgkb.org |
CCLE, Cancer Cell Line Encyclopedia; CMap, Connectivity Map; CNVs, copy number variants; COSMIC, catalog of somatic mutations in cancer; CTRP, Cancer Therapeutics Response Portal; dbSNP, Single Nucleotide Polymorphism Database; dbVar, database of genomic structural variation; EBI, European Bioinformatics Institute; ENCODE, Encyclopedia of DNA Elements; GEO, Gene Expression Omnibus; GTEx, Genotype-Tissue Expression; IMMPORT, Immunology Database and Analysis Portal; LINCS, Library of Integrated Network-based Cellular Signatures; NCBI, National Center for Biotechnology Information; SNPs, single-nucleotide polymorphisms; TCGA, The Cancer Genome Atlas.
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